Which approach will achieve this goal?
Use EC2 instances in multiple AWS Regions.
Use EC2 instances in multiple Amazon CloudFront locations.
Use EC2 instances in multiple edge locations.
Use EC2 instances in AWS Local Zones.
Explanations:
Using EC2 instances in multiple AWS Regions ensures high availability even in the event of a regional failure due to natural disasters. Regions are geographically separated and isolated from each other.
CloudFront is a Content Delivery Network (CDN) service, not designed for running EC2 instances. It helps deliver content to users globally but does not provide high availability for EC2 instances.
Edge locations are part of the CloudFront network and are used for content caching, not for running EC2 instances. They do not provide high availability for EC2 workloads.
AWS Local Zones are extensions of an AWS Region, providing low-latency access to AWS services in specific geographic areas, but they are not sufficient for ensuring availability in case of regional disasters. Local Zones are typically used for specific use cases like latency-sensitive applications.
I measure that the answer is:
Use EC2 instances in multiple AWS Regions.