What is the MOST operationally efficient solution that will resolve this connectivity issue?
Create a VPC peering connection between the two Regions. Add the private IP address range of the instances to the inbound rule of the database security group.
Create a VPC peering connection between the two Regions. Add the security group of the instances in eu-central-1 to the outbound rule of the database security group.
Create a VPN connection between the two Regions. Add the private IP address range of the instances to the outbound rule of the database security group.
Create a VPN connection between the two Regions. Add the security group of the instances in eu-central-1 to the inbound rule of the database security group.